House File 728 H-1226 Amend House File 728 as follows: 1 1. By striking everything after the enacting clause and 2 inserting: 3 < DIVISION I 4 IOWA PRESCRIPTION MONITORING PROGRAM INFORMATION 5 Section 1. Section 124.554, subsection 1, paragraph g, Code 6 2019, is amended to read as follows: 7 g. Including all schedule schedules II , III, and IV 8 controlled substances, those substances in schedules III and IV 9 that the advisory council and board determine can be addictive 10 or fatal if not taken under the proper care and direction 11 of a prescribing practitioner, and schedule V controlled 12 substances including when dispensed by a pharmacist without 13 a prescription, except for sales of pseudoephedrine which 14 are reported to the real-time electronic repository, opioid 15 antagonists , and other prescription substances that the board 16 and advisory council determine can be addictive or fatal if 17 not taken under the proper care and direction of a prescribing 18 practitioner . 19 Sec. 2. Section 124.554, subsection 2, unnumbered paragraph 20 1, Code 2019, is amended to read as follows: 21 Beginning January February 1, 2007 2020 , and annually by 22 January February 1 thereafter, the board and advisory council 23 shall present to the general assembly and the governor a 24 report prepared consistent with section 124.555, subsection 3 , 25 paragraph “d” , which shall include but not be limited to the 26 following: 27 DIVISION II 28 CONTROLLED SUBSTANCE SCHEDULES 29 Sec. 3. Section 124.204, subsection 2, Code 2019, is amended 30 by adding the following new paragraph: 31 NEW PARAGRAPH . be. MT-45 (1-cyclohexyl-4-(1,2- 32 diphenylethyl)piperazine). 33 Sec. 4. Section 124.204, subsection 4, paragraph m, Code 34 2019, is amended to read as follows: 35 -1- HF728.1853 (1) 88 (amending this HF 728 to CONFORM to SF 572) ss/rh 1/ 5 #1.

m. Marijuana , except as otherwise provided by rules of the 1 board for medicinal purposes . 2 Sec. 5. Section 124.204, subsection 4, paragraph u, 3 unnumbered paragraph 1, Code 2019, is amended to read as 4 follows: 5 Tetrahydrocannabinols, except as otherwise provided 6 by rules of the board for medicinal purposes, meaning 7 tetrahydrocannabinols naturally contained in a plant of 8 the genus Cannabis (Cannabis plant) as well as synthetic 9 equivalents of the substances contained in the Cannabis plant, 10 or in the resinous extractives of such plant, and synthetic 11 substances, derivatives, and their isomers with similar 12 chemical structure and pharmacological activity to those 13 substances contained in the plant, such as the following: 14 Sec. 6. Section 124.204, subsection 6, paragraph i, Code 15 2019, is amended by adding the following new subparagraph: 16 NEW SUBPARAGRAPH . (27) 1-(1,3-benzodioxol-5-yl)-2- 17 (ethylamino)-pentan-1-one. Other names: N-ethylpentylone or 18 ephylone. 19 Sec. 7. Section 124.204, subsection 7, Code 2019, is amended 20 by striking the subsection. 21 Sec. 8. Section 124.204, subsection 9, Code 2019, is amended 22 by adding the following new paragraphs: 23 NEW PARAGRAPH . af. N-(1-phenethylpiperidin-4-yl)-N- 24 phenylcyclopropanecarboxamide, its isomers, esters, ethers, 25 salts and salts of isomers, esters, and ethers. Other name: 26 cyclopropyl fentanyl. 27 NEW PARAGRAPH . ag. N-(1-phenethylpiperidin-4-yl)-N- 28 phenylpentanamide, its isomers, esters, ethers, salts and salts 29 of isomers, esters and ethers. Other name: valeryl fentanyl. 30 NEW PARAGRAPH . ah. N-(4-fluorophenyl)-N-(1- 31 phenethylpiperidin-4-yl)butyramide, its isomers, esters, 32 ethers, salts and salts of isomers, esters, and ethers. Other 33 name: para-fluorobutyryl fentanyl. 34 NEW PARAGRAPH . ai. N-(4-methoxyphenyl)-N- 35 -2- HF728.1853 (1) 88 (amending this HF 728 to CONFORM to SF 572) ss/rh 2/ 5

(1-phenethylpiperidin-4-yl)butryamide, its isomers, esters, 1 ethers, salts and salts of isomers, esters, and ethers. Other 2 name: para-methyoxybutyryl fentanyl. 3 NEW PARAGRAPH . aj. N-(4-chlorophenyl)-N-(1- 4 phenethylpiperidin-4-yl)isobutryramide, its isomers, esters, 5 ethers, salts and salts of isomers, esters, and ethers. Other 6 name: para-chloroisobutyryl fentanyl. 7 NEW PARAGRAPH . ak. N-(1-phenethylpiperidin-4-yl)- 8 N-phenylisobutyramide, its isomers, esters, ethers, salts and 9 salts of isomers, esters, and ethers. Other name: isobutyryl 10 fentanyl. 11 NEW PARAGRAPH . al. N-(1-phenethylpiperidin-4-yl)- 12 N-phenylcyclopentanecarboxamide, its isomers, esters, ethers, 13 salts and salts of isomers, esters, and ethers. Other name: 14 cyclopentyl fentanyl. 15 NEW PARAGRAPH . am. N-(2-fluorophenyl)-2-methoxy-N- 16 (1-phenethylpiperidin-4-yl)acetamide, its isomers, esters, 17 ethers, salts and salts of isomers, esters, and ethers. Other 18 name: ocfentanil. 19 NEW PARAGRAPH . an. Fentanyl-related substances, their 20 isomers, esters, ethers, salts and salts of isomers, esters 21 and ethers. “Fentanyl-related substance” means any substance 22 not otherwise listed under this schedule or another schedule, 23 and for which no exemption or approval is in effect under 24 section 505 of the federal Food, Drug, and Cosmetic Act that 25 is structurally related to fentanyl by one or more of the 26 following modifications: 27 (1) Replacement of the phenyl portion of the phenethyl group 28 by any monocycle, whether or not further substituted in or on 29 the monocycle. 30 (2) Substitution in or on the phenethyl group with alkyl, 31 alkenyl, alkoxyl, hydroxyl, halo, haloalkyl, amino, or nitro 32 groups. 33 (3) Substitution in or on the piperidine ring with alkyl, 34 alkenyl, alkoxyl, ester, ether, hydroxyl, halo, haloalkyl, 35 -3- HF728.1853 (1) 88 (amending this HF 728 to CONFORM to SF 572) ss/rh 3/ 5

amino, or nitro groups. 1 (4) Replacement of the aniline ring with any aromatic 2 monocycle whether or not further substituted in or on the 3 aromatic monocycle. 4 (5) Replacement of the N -propionyl group by another acyl 5 group. 6 NEW PARAGRAPH . ao. Naphthalen-1-yl 1-(5-fluoropentyl)- 7 1 H -indole-3-carboxylate. Other names: NM2201 or CBL2201. 8 NEW PARAGRAPH . ap. N -(1-amino-3-methyl-1-oxobutan- 9 2-yl)-1-(5-fluoropentyl)-1 H -indazole-3-carboxamide. Other 10 name: 5F-AB-PINACA. 11 NEW PARAGRAPH . aq. 1-(4-cyanobutyl)- N -(2-phenylpropan- 12 2-yl)-1 H -indazole-3-carboxamide. Other names: 13 4-CN-CUMYL-BUTINACA, 4-cyano-CUMYL-BUTINACA, 4-CN-CUMYL 14 BINACA, CUMYL-4CN-BINACA, or SGT-78. 15 NEW PARAGRAPH . ar. Methyl 2-(1-(cyclohexylmethyl)-1 H - 16 indole-3-carboxamido)-3-methylbutanoate. Other names: 17 MMB-CHMICA or AMB-CHMICA. 18 NEW PARAGRAPH . as. 1-(5-fluoropentyl)- N -(2- 19 phenylpropan-2-yl)-1 H -pyrrolo[2,3-b]pyridine-3-carboxamide. 20 Other name: 5F-CUMYL-P7AICA. 21 Sec. 9. Section 124.206, subsection 7, paragraph a, Code 22 2019, is amended by striking the paragraph. 23 Sec. 10. Section 124.208, subsection 3, paragraph c, Code 24 2019, is amended to read as follows: 25 c. Any substance which contains any quantity of a derivative 26 of barbituric acid or any salt thereof including but not 27 limited to Fioricet . 28 Sec. 11. Section 124.212, Code 2019, is amended by adding 29 the following new subsection: 30 NEW SUBSECTION . 6. Approved cannabidiol drugs. A drug 31 product in finished dosage formulation that 32 has been approved by the United States food and 33 drug administration that contains cannabidiol 34 (2-[1R-3-methyl-6R-(1-methylethenyl)-2-cyclohexen-1-yl]-5- 35 -4- HF728.1853 (1) 88 (amending this HF 728 to CONFORM to SF 572) ss/rh 4/ 5

pentyl-1,3-benzenediol) derived from cannabis and no more than 1 0.1 percent (w/w) residual tetrahydrocannabinols. 2 Sec. 12. EFFECTIVE DATE. This division of this Act, being 3 deemed of immediate importance, takes effect upon enactment. > 4 ______________________________ JENEARY of Plymouth -5- HF728.1853 (1) 88 (amending this HF 728 to CONFORM to SF 572) ss/rh 5/ 5